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pentobarbital will lower the level or result of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the extent or impact of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not advisable; solid cytochrome P450 enzyme inducers decrea